SUPPLEMENTAL MATERIALS

Physiological signature

Functional groups:

·      Virus gateways (54 genes): HIF1A, ATP6V1C1, S100A9, HSPA5, ATP6V1D, PPIA, HAT1, SLC16A7, CD44, HDAC2, GADD45GIP, FLT, SLC2A1, CYB5B, PTGES3, FURIN, BSG, HMGB2, PSENEN, APH1B, TLR3, SLC3A2, METTL4, ATP6V1E1, IL13RA1, ADAM10, NCSTN, PSEN1, NOD2, SLC16A4, NFATC4, ACE2, KDM5B, VWF, NFATC3, CLDN5, GP6, SPN, GAS5, DICER1, SLC16A8, CD34, NFAT5, APH1A, HMGB1, PECAM1, TMPRSS2, KAT2B, NXNL1, APOD, ITGA6, TIE1 and KDR.

·      Intracellular traffic (66 genes): SLC16A3, RAB10, KPNA2, SLC16A1, SLC7A5, LMAN2, FKBP10, AP3B1, SIGMAR1, HEATR3, RAB18, FKBP15, GRPEL1, SLC16A7, FKBP1A, RAB2A, SRP72, NUP62, TMED5, POR, RAB1A, RAB7A, NUTF2, YIF1A, VTA1, GOLGA3, NUP155, NPC2, AP2M1, ERGIC1, FURIN, RAB8A, FKBP7, PCSK6, SLC30A7, SLC30A6, ARF6, RAB5C, SRP54, GOLGA2, KPNA3, NUP98, SLC3A2, AP2A2, REEP5, GCC1, GOLGA7, KPNA1, SLC16A4, SLC27A2, SLC30A9, NUP88, RTN4, RAB14, NUP214, SLC25A21, NUP54, SLC16A8, NUP153, REEP6, RALA, USP6NL, GORASP1, VPS39, GOLGB1 and SLC44A2.

·      Transcription/(post)translation physiology (79 genes): NME1, PPIB, ATP6V1C1, SIL1, ERP44, HYOU1, NOL10, FKBP10, CCDC86, HEATR3, HSPA5, ATP6V1D, FKBP15, IMPDH2, PPIA, HAT1, EXOSC3, MRPS5, SRP19, DDX21, EXOSC5, FKBP1A, GTF2F2, RRP9, NUP62, HDAC2, EIF4E2, MRPS27, TOR1A, RBM28, TRMT1, MDFI, DDX10, EXOSC2, UBXN8, RAE1, FKBP7, TLE3, H2AFB1, PRIM2, PPIL3, PABPC1, NGLY1, EDEM3, POLA2, LARP1, OS9, SDF2, UGGT2, POLA1, EXOSC8, INTS4, PRIM1, EIF4H, RPL36, NFATC4, HTATSF1, MDN1, UPF1, LARP1B, MOV10, KDM5B, ERLEC1, LARP7, NEAT1, CRTC3, TPR, PTBP2, ATE1, LARP4B, ELF3, RBM41, KAT2B, AKAP8L, SNIP1, ZC3H7A, TLE1, ZNF503 and LUC7L3.

·      Mitochondrial physiology (42 genes): BCKDK, HIF1A, ATP6V1C1, NDUFAF2, HYOU1, AP3B1, GPX1, ATP6V1D, ETFA, GRPEL1, ATP6V1A, TIMM8B, MRPS5, STOML2, TIMM10, TIMM9, NDUFAF1, MRPS27, COX8A, ATP6AP1, ALAS1, CYB5B, MRPS2, TOMM70A, ACAD9, ATP13A3, NDUFB9, TARS2, ACADM, BCS1L, GFER, ECSIT, FASTKD5, MRPS25, PITRM1, ATP1B1, PMPCA, PMPCB, CYB5R3, REEP6, AASS and USP54.


Table S1. Correlation between COVID-19-Signature (transcription level) and the MEL-Index in human normal lungs.


GENES

r

p

FDR

CTSB

-0.41646

2.21E-13

1.00E-10

SLC16A3

-0.41623

2.28E-13

1.03E-10

BZW2

-0.39233

6.35E-12

2.86E-09

NME1

-0.39134

7.24E-12

3.26E-09

BCKDK

-0.38833

1.08E-11

4.85E-09

PPIB

-0.38591

1.48E-11

6.61E-09

RAB10

-0.3706

1.04E-10

4.65E-08

HIF1A

-0.36968

1.17E-10

5.20E-08

KPNA2

-0.36716

1.60E-10

7.07E-08

ATP6V1C1

-0.3667

1.69E-10

7.47E-08

SLC16A1

-0.36092

3.40E-10

1.50E-07

SLC7A5

-0.34244

2.92E-09

1.28E-06

SIL1

-0.34236

2.94E-09

1.29E-06

NDUFAF2

-0.34224

2.99E-09

1.30E-06

ERP44

-0.33827

4.65E-09

2.03E-06

HS2ST1

-0.32955

1.21E-08

5.24E-06

LMAN2

-0.3295

1.21E-08

5.26E-06

HYOU1

-0.32675

1.63E-08

7.04E-06

G3BP1

-0.31754

4.26E-08

1.84E-05

NOL10

-0.31579

5.10E-08

2.19E-05

MIF

-0.31036

8.83E-08

3.78E-05

S100A9

-0.3095

9.63E-08

4.11E-05

FKBP10

-0.30839

1.08E-07

4.58E-05

AP3B1

-0.29563

3.72E-07

0.000157

GPX1

-0.29515

3.89E-07

0.000164

CCDC86

-0.2939

4.38E-07

0.000184

SIGMAR1

-0.29197

5.24E-07

0.00022

HEATR3

-0.29089

5.80E-07

0.000243

HSPA5

-0.2905

6.02E-07

0.000251

ATP6V1D

-0.28927

6.75E-07

0.000281

RAB18

-0.28763

7.85E-07

0.000326

FKBP15

-0.28492

1.01E-06

0.000416

FTH1

-0.28253

1.25E-06

0.000516

ETFA

-0.28241

1.26E-06

0.00052

GRPEL1

-0.2814

1.38E-06

0.000568

ATP6V1A

-0.27621

2.19E-06

0.000898

IMPDH2

-0.27125

3.38E-06

0.001381

PPIA

-0.26951

3.92E-06

0.001596

CLIC1

-0.26878

4.17E-06

0.001695

HAT1

-0.2685

4.28E-06

0.001732

TYMP

-0.26795

4.48E-06

0.001809

GLA

-0.26697

4.87E-06

0.001962

PPT1

-0.26194

7.43E-06

0.002971

TIMM8B

-0.26139

7.77E-06

0.003101

EXOSC3

-0.26054

8.34E-06

0.003319

MRPS5

-0.25879

9.63E-06

0.003822

SRP19

-0.25855

9.83E-06

0.003891

PSMD8

-0.25829

1.00E-05

0.003963

SLC16A7

-0.25728

1.09E-05

0.004294

SCCPDH

-0.25301

1.54E-05

0.006034

DDX21

-0.25286

1.56E-05

0.006091

MMP9

-0.25247

1.61E-05

0.006268

HMOX1

-0.25192

1.68E-05

0.00653

HSBP1

-0.25058

1.87E-05

0.007226

CD44

-0.24897

2.12E-05

0.008186

EXOSC5

-0.24858

2.19E-05

0.008421

DCTPP1

-0.2476

2.36E-05

0.009046

STOML2

-0.24506

2.88E-05

0.010998

IL17RA

-0.24456

2.99E-05

0.011397

FKBP1A

-0.2429

3.40E-05

0.012926

S100P

-0.24128

3.85E-05

0.014583

GTF2F2

-0.23894

4.60E-05

0.017377

GDF15

-0.23819

4.87E-05

0.018343

RAB2A

-0.2378

5.01E-05

0.018833

SCARB1

-0.23618

5.65E-05

0.021201

TIMM10

-0.2314

8.05E-05

0.029929

SRP72

-0.23094

8.33E-05

0.030886

PDZD11

-0.2309

8.35E-05

0.030886

TIMM9

-0.22712

0.00011

0.040055

NQO1

-0.22673

0.000113

0.040951

PLAT

-0.22656

0.000114

0.041333

RRP9

-0.22483

0.000129

0.046635

ALG8

-0.22473

0.00013

0.046828

NUP62

-0.22447

0.000133

0.047576

HDAC2

-0.22152

0.000163

0.058401

TMED5

-0.21948

0.000188

0.066929

GGCX

-0.21671

0.000228

0.080486

EIF4E2

-0.21526

0.000251

0.088446

POR

-0.21119

0.00033

0.114646

RAB1A

-0.20806

0.000406

0.140635

RAP1GDS1

-0.20802

0.000408

0.140635

NDUFAF1

-0.20511

0.000493

0.169113

IL6

-0.20494

0.000498

0.170472

MRPS27

-0.20319

0.000558

0.190262

GNG5

-0.2014

0.000626

0.212107

COX8A

-0.20123

0.000633

0.21387

ACSL3

-0.20026

0.000673

0.226672

CHPF2

-0.19972

0.000696

0.233869

FAM162A

-0.19849

0.000752

0.25196

RAB7A

-0.1979

0.000781

0.260805

TOR1A

-0.19566

0.000898

0.29722

RBM28

-0.19454

0.000962

0.317574

ATP6AP1

-0.19221

0.00111

0.364119

NUTF2

-0.19096

0.001197

0.391492

YIF1A

-0.18953

0.001305

0.424226

VTA1

-0.18931

0.001323

0.428541

TRMT1

-0.18887

0.001358

0.438615

GADD45GIP1

-0.18725

0.001496

0.480351

FLT1

-0.18051

0.00222

0.70599

GHITM

-0.18046

0.002226

0.70599

CISD3

-0.18037

0.002238

0.707092

SLC2A1

-0.17981

0.002311

0.72332

ALAS1

-0.17801

0.00256

0.798732

NEU1

-0.17547

0.002956

0.916369

GOLGA3

-0.17534

0.002977

0.919936

MDFI

-0.17505

0.003025

0.93172

DDX10

-0.17435

0.003146

0.962752

EXOSC2

-0.17051

0.003889

1

ACTG1

-0.16821

0.004406

1

CYB5B

-0.16801

0.004453

1

NEDD8

-0.16501

0.00523

1

PTGES2

-0.16469

0.005317

1

GGH

-0.16429

0.005431

1

CENPF

-0.1632

0.005752

1

NUP155

-0.16221

0.006059

1

PVR

-0.16088

0.006495

1

NPC2

-0.16036

0.006669

1

QSOX2

-0.15961

0.006934

1

AP2M1

-0.15948

0.006982

1

ERGIC1

-0.15792

0.007562

1

IDE

-0.15719

0.007847

1

AGPS

-0.15699

0.007926

1

CHPF

-0.15594

0.008361

1

PTGES3

-0.15557

0.008518

1

MRPS2

-0.15458

0.008951

1

PRKACA

-0.15383

0.009293

1

FURIN

-0.15273

0.009817

1

RAB8A

-0.15257

0.009896

1

CUL2

-0.15141

0.010476

1

ZDHHC5

-0.15088

0.010757

1

POFUT1

-0.15055

0.010931

1

UBXN8

-0.15024

0.011096

1

CWC27

-0.14943

0.011547

1

RAE1

-0.1492

0.011673

1

BSG

-0.1473

0.012798

1

CD59

-0.14711

0.012915

1

HMGB2

-0.14317

0.015571

1

FKBP7

-0.14247

0.016091

1

TLE3

-0.14129

0.016999

1

TOMM70A

-0.13958

0.018398

1

ALG5

-0.13892

0.018956

1

PCSK6

-0.13792

0.019843

1

PPARG

-0.13779

0.019959

1

STC2

-0.13676

0.020918

1

SLC30A7

-0.13554

0.022093

1

LOXL1

-0.13384

0.023836

1

SLC30A6

-0.13375

0.02393

1

HS6ST2

-0.13351

0.024192

1

ADAMTS1

-0.13279

0.024975

1

ARF6

-0.13269

0.025085

1

CSTA

-0.13196

0.025899

1

RAB5C

-0.13036

0.027776

1

SRP54

-0.12785

0.030947

1

GRN

-0.1278

0.031013

1

ADAM9

-0.12511

0.03476

1

TMSB10

-0.12399

0.036428

1

FBN1

-0.12333

0.037452

1

H2AFB1

-0.1223

0.039086

1

ITGB1

-0.12165

0.040144

1

F2RL1

-0.12088

0.041426

1

DPY19L1

-0.11687

0.048719

1

PRIM2

-0.11627

0.049885

1

AGT

-0.11622

0.049983

1

RNF41

-0.11572

0.050993

1

CDK5RAP2

-0.11369

0.055236

1

TBK1

-0.10721

0.070748

1

TMEM97

-0.1068

0.071836

1

PPIL3

-0.10505

0.07664

1

ALG11

-0.10423

0.078967

1

PSENEN

-0.10249

0.084127

1

GOLGA2

-0.10116

0.088246

1

KPNA3

-0.09775

0.099578

1

PABPC1

-0.09752

0.100378

1

KPNA4

-0.09701

0.102184

1

NGLY1

-0.0949

0.1099

1

SPCS1

-0.09394

0.11354

1

NUP98

-0.09274

0.118275

1

APH1B

-0.09257

0.118951

1

IFI6

-0.09244

0.11945

1

DNMT1

-0.09207

0.120938

1

THTPA

-0.09206

0.120997

1

EDEM3

-0.08927

0.132727

1

LGALS3

-0.08924

0.132874

1

ITGAV

-0.08866

0.135394

1

ABCC1

-0.08648

0.145306

1

PKP2

-0.08644

0.145495

1

RHOA

-0.08455

0.154551

1

TLR3

-0.08417

0.156421

1

CAB39

-0.08389

0.157811

1

NPC1

-0.08379

0.158312

1

ACAD9

-0.08365

0.159011

1

POLA2

-0.08302

0.162158

1

LARP1

-0.08246

0.165039

1

GPX2

-0.08208

0.166986

1

IL6ST

-0.08201

0.167346

1

STOM

-0.0818

0.168465

1

OS9

-0.08128

0.171197

1

SLC3A2

-0.08073

0.174087

1

ATP13A3

-0.07984

0.178914

1

CD4

-0.07942

0.181244

1

DPH5

-0.07806

0.188819

1

AP2A2

-0.07772

0.190804

1

METTL4

-0.07745

0.192329

1

DNAJC11

-0.07722

0.193674

1

INS

-0.07719

0.19384

1

SDF2

-0.07697

0.195094

1

ATP6V1E1

-0.07682

0.196011

1

IL13RA1

-0.0765

0.197869

1

ADAM10

-0.07375

0.214514

1

NARS2

-0.07083

0.233262

1

TBCA

-0.07082

0.23333

1

UGGT2

-0.07041

0.236062

1

GPAA1

-0.06802

0.252404

1

CHMP2B

-0.06575

0.268567

1

NEK9

-0.06239

0.293899

1

PRKAR2A

-0.06215

0.295726

1

TMEM39B

-0.06012

0.311808

1

C1orf50

-0.05985

0.314006

1

FOXRED2

-0.05854

0.324734

1

REEP5

-0.05823

0.327276

1

PUSL1

-0.05812

0.328253

1

POLA1

-0.05523

0.352908

1

NCSTN

-0.05438

0.360359

1

COL6A1

-0.05333

0.369722

1

EXOSC8

-0.05243

0.377831

1

CHMP2A

-0.0506

0.394774

1

GCC1

-0.04804

0.419122

1

PSEN1

-0.04765

0.422969

1

NDUFB9

-0.04688

0.430501

1

SAAL1

-0.04634

0.43581

1

NOC4L

-0.04145

0.485797

1

SERPINB3

-0.04099

0.490648

1

INTS4

-0.04094

0.491185

1

XIAP

-0.04006

0.500567

1

CEACAM5

-0.03957

0.505822

1

FBN2

-0.03535

0.552324

1

DCAF7

-0.03489

0.557525

1

BRD4

-0.03454

0.561443

1

GOLGA7

-0.03408

0.566647

1

KPNA1

-0.03405

0.567042

1

MYCBP2

-0.03363

0.571828

1

PRIM1

-0.03326

0.57604

1

PIGS

-0.0329

0.58023

1

EIF4H

-0.03221

0.588122

1

GIGYF2

-0.03178

0.593087

1

PLAC8

-0.03147

0.596703

1

CEP135

-0.03049

0.608233

1

NOD2

-0.02996

0.614441

1

PTH

-0.0298

0.616397

1

EDN1

-0.02963

0.618387

1

NIN

-0.02903

0.625567

1

SLC16A4

-0.0285

0.631806

1

ENG

-0.02766

0.641951

1

SBNO1

-0.02749

0.643948

1

CEP250

-0.02685

0.651729

1

TARS2

-0.02639

0.657285

1

SLC27A2

-0.0259

0.663248

1

ACADM

-0.02434

0.68237

1

G3BP2

-0.02369

0.690419

1

BCS1L

-0.02126

0.720812

1

MOGS

-0.02106

0.723361

1

SLC30A9

-0.0198

0.739301

1

CLCC1

-0.01793

0.763086

1

GFER

-0.01688

0.776637

1

RPL36

-0.01492

0.801927

1

ZC3H18

-0.01394

0.814761

1

NUP88

-0.01374

0.817394

1

MARK2

-0.01286

0.828894

1

CEP350

-0.01281

0.829516

1

NFATC4

-0.01253

0.833197

1

MPHOSPH10

-0.01242

0.834639

1

RANBP2

-0.01229

0.836285

1

NDFIP2

-0.01145

0.847422

1

FAR2

-0.01094

0.854167

1

ITCH

-0.00738

0.901243

1

MDK

-0.00712

0.904697

1

MIPOL1

-0.00675

0.909622

1

GNB1

-0.0062

0.917067

1

VEGFA

-0.00522

0.930056

1

PIGR

-0.00512

0.931375

1

HTATSF1

-0.0044

0.941011

1

PLD3

-0.00289

0.961224

1

PIGO

-0.00263

0.964727

1

ACE2

-0.00047

0.993694

1

NAT14

0.001688

0.977361

1

SCAP

0.006195

0.917071

1

MDN1

0.006656

0.910929

1

RBX1

0.006993

0.90644

1

PTMA

0.007454

0.900302

1

ECSIT

0.009142

0.877875

1

REN

0.009598

0.871832

1

PDE4DIP

0.010412

0.861074

1

ERMP1

0.011901

0.841454

1

RTN4

0.012488

0.833738

1

UPF1

0.01347

0.820886

1

COMT

0.014049

0.813325

1

JAKMIP1

0.018738

0.752788

1

FASTKD5

0.018962

0.749921

1

LARP1B

0.019677

0.740822

1

NUP107

0.023049

0.698417

1

MOV10

0.024453

0.681024

1

RAB14

0.024632

0.67882

1

ALDH3A1

0.024939

0.675044

1

MRPS25

0.02503

0.673931

1

DEK

0.025755

0.665042

1

KDM5B

0.026864

0.651556

1

TUBGCP2

0.029499

0.619954

1

PITRM1

0.032215

0.588092

1

ERLEC1

0.032668

0.582855

1

ATP1B1

0.033637

0.571713

1

PMPCA

0.033787

0.57

1

TGFB1

0.033874

0.569015

1

INHBE

0.03406

0.566887

1

TYSND1

0.036051

0.544431

1

VWF

0.03675

0.536647

1

CLIP4

0.038602

0.516308

1

TBKBP1

0.038692

0.515321

1

TUBGCP3

0.044351

0.455782

1

SLC9A3R1

0.044875

0.450471

1

IFNA1

0.045285

0.446341

1

TRIM59

0.047732

0.422137

1

CST3

0.048059

0.418959

1

NFATC3

0.051641

0.385092

1

ACE

0.05191

0.382622

1

CLDN5

0.053284

0.370137

1

HOOK1

0.054296

0.361104

1

GP6

0.055704

0.348768

1

DSTN

0.057028

0.337415

1

MAP7D1

0.057888

0.330168

1

GRIPAP1

0.058609

0.324163

1

SPN

0.058734

0.323136

1

CSDE1

0.060852

0.305962

1

NUP214

0.060935

0.305303

1

GAS5

0.062115

0.296009

1

ERC1

0.063089

0.28849

1

LOX

0.065333

0.271645

1

CSNK2B

0.06536

0.271453

1

SLC25A21

0.065896

0.267531

1

SLU7

0.06639

0.263954

1

BAG5

0.071299

0.230175

1

FYCO1

0.073518

0.215955

1

TCF12

0.075737

0.202379

1

SEPP1

0.075771

0.202178

1

MTCH1

0.079197

0.182463

1

CAPSL

0.07972

0.179579

1

NLRX1

0.080649

0.174546

1

DNAJC19

0.081462

0.170227

1

PLD2

0.081671

0.169129

1

LARP7

0.081758

0.168677

1

NPPB

0.082767

0.163465

1

NPTX1

0.082918

0.162691

1

TNF

0.08297

0.162431

1

ARL6IP6

0.084402

0.155273

1

DICER1

0.085168

0.151548

1

NUP54

0.085582

0.149561

1

RIPK1

0.085986

0.147642

1

VPS11

0.086537

0.145055

1

ZYG11B

0.086869

0.143512

1

PMPCB

0.087163

0.142154

1

MAT2B

0.087379

0.141169

1

MARK1

0.088975

0.134017

1

MFGE8

0.090043

0.129393

1

CYB5R3

0.094713

0.1106

1

NFU1

0.097425

0.100715

1

DCAKD

0.097925

0.098969

1

TOR1AIP1

0.098518

0.096933

1

CD151

0.100276

0.091091

1

NFATC1

0.100342

0.090875

1

SMOC1

0.101575

0.086958

1

TM2D3

0.101688

0.086604

1

SPAG16

0.106567

0.072453

1

OPTN

0.109596

0.064655

1

ANO6

0.109802

0.064151

1

SLC16A8

0.111075

0.061108

1

SLC44A4

0.112753

0.057276

1

SIRT5

0.113147

0.056407

1

IL6R

0.11328

0.056116

1

TSPAN1

0.118645

0.045367

1

UBAP2L

0.12209

0.03942

1

USP13

0.124304

0.035958

1

CD34

0.124431

0.035766

1

NEAT1

0.12491

0.035056

1

AKAP8

0.126961

0.032144

1

PLA2G10

0.127034

0.032045

1

NUP153

0.127327

0.031647

1

REEP6

0.127807

0.031006

1

CRTC3

0.128714

0.029823

1

RALA

0.129018

0.029435

1

NFAT5

0.130683

0.027387

1

APH1A

0.133563

0.024133

1

TPR

0.133836

0.023842

1

PTBP2

0.135224

0.022412

1

CSNK2A2

0.135711

0.021928

1

CA2

0.137972

0.019798

1

IST1

0.141523

0.016815

1

HMGB1

0.143877

0.015061

1

UBAP2

0.149209

0.011669

1

ATE1

0.150831

0.01078

1

ZNF318

0.15321

0.009586

1

TFF3

0.153293

0.009546

1

USP6NL

0.15341

0.009491

1

CLDN3

0.153847

0.009286

1

CEP68

0.155269

0.008648

1

PECAM1

0.157227

0.007833

1

LARP4B

0.159278

0.007053

1

LAMB3

0.160905

0.006485

1

MEPCE

0.163798

0.005574

1

ELF3

0.167432

0.004594

1

TMPRSS2

0.169056

0.004209

1

SORBS2

0.170178

0.00396

1

CIT

0.170364

0.00392

1

RBM41

0.17266

0.003455

1

KAT2B

0.17482

0.003065

0.94089

NINL

0.177143

0.00269

0.836507

AKAP8L

0.179877

0.002302

0.722827

NXNL1

0.180226

0.002256

0.710725

MIB1

0.181745

0.002067

0.659394

GCC2

0.184617

0.001748

0.559481

APOD

0.188553

0.001384

0.445777

ITGA6

0.189816

0.001283

0.418331

CLDN4

0.192921

0.001063

0.349636

SNIP1

0.196798

0.000836

0.277681

EGFR

0.197612

0.000795

0.264721

PLEKHF2

0.203192

0.000558

0.190262

BRD2

0.205384

0.000484

0.166588

FBXL12

0.211416

0.000325

0.113261

ZC3H7A

0.211958

0.000314

0.109546

AASS

0.212452

0.000304

0.106281

GORASP1

0.212715

0.000298

0.104719

HECTD1

0.216721

0.000227

0.080486

ID4

0.218854

0.000196

0.069698

EPS15

0.219647

0.000186

0.066348

VPS39

0.227016

0.000111

0.040234

FAM8A1

0.227878

0.000104

0.038085

TLE1

0.227894

0.000104

0.038085

TIE1

0.228615

9.85E-05

0.036255

NFATC2

0.228959

9.61E-05

0.035463

ZNF503

0.233729

6.78E-05

0.02533

SEPSECS

0.233749

6.77E-05

0.02533

PCNT

0.247644

2.35E-05

0.009038

PDE5A

0.251562

1.73E-05

0.006702

PRKAR2B

0.257081

1.11E-05

0.004353

MARK3

0.263999

6.25E-06

0.002508

GOLGB1

0.266484

5.07E-06

0.002039

LUC7L3

0.269552

3.91E-06

0.001594

KDR

0.293332

4.62E-07

0.000194

FBLN5

0.300646

2.30E-07

9.75E-05

USP54

0.30218

1.98E-07

8.42E-05

SUN2

0.312798

6.91E-08

2.97E-05

TAPT1

0.322906

2.44E-08

1.05E-05

PLEKHA5

0.343144

2.70E-09

1.19E-06

AKAP9

0.38692

1.30E-11

5.81E-09

SLC44A2

0.387422

1.22E-11

5.45E-09

WFS1

0.398271

2.85E-12

1.29E-09

Table S2. Top 40 most connected genes in the normal lung tissue Low, Medium, and High MEL-Index subgroups of the samples.


MEL-Index

Low

Medium

High

1

TOR1A

REEP5

STOML2

2

SDF2

RAB14

NDUFAF1

3

ZDHHC5

COMT

EXOSC5

4

GPAA1

HDAC2

ALG5

5

STOML2

CYB5B

GHITM

6

RAE1

RAB5C

EIF4E2

7

ETFA

FBXL12

SLC30A6

8

GHITM

CHMP2A

TIMM8B

9

CISD3

CD151

ATP6V1D

10

MRPS2

PMPCB

VTA1

11

PIGO

PMPCA

CISD3

12

EIF4H

EIF4H

TOR1A

13

YIF1A

GHITM

MRPS2

14

ATP6V1E1

AP2M1

KDM5B

15

SPCS1

PSMD8

IST1

16

RAB5C

ZDHHC5

MRPS27

17

ATP6V1D

CYB5R3

PPT1

18

PUSL1

RAB7A

ACADM

19

DNAJC19

GNB1

ATP6V1E1

20

GTF2F2

SRP19

TMEM97

21

HDAC2

ERP44

TBK1

22

CHMP2A

ATP6V1E1

ATP6V1A

23

SCAP

OS9

NDUFB9

24

NDUFB9

RAP1GDS1

RRP9

25

NEDD8

RBX1

PIGO

26

PSMD8

EXOSC8

HTATSF1

27

RAB14

TOR1A

ERLEC1

28

COMT

SDF2

EXOSC2

29

REEP5

GPAA1

ETFA

30

VTA1

GORASP1

GRIPAP1

31

HTATSF1

GOLGA7

OPTN

32

GOLGA7

RHOA

PRIM1

33

MRPS27

QSOX2

BCS1L

34

PDZD11

ATP6AP1

ITGAV

35

NUP62

AKAP8

AGPS

36

RBX1

PUSL1

ALG8

37

VPS11

GNG5

LUC7L3

38

OS9

PTGES2

KPNA3

39

PIGS

TOMM70A

ACAD9

40

RNF41

BCKDK

SIGMAR1

 Table S3. Genes associated with ACE2 and CD147 virus gateways.

S3.png

CCBY.png

This work is licensed under a Creative Commons Attribution 4.0 International License

Please cite this paper as:

Fernandes, P.A., Kinker, G.S., Navarro, B.V., Jardim, V.C., Ribeiro-Paz, E.D., Córdoba-Moreno, M.O., Santos-Silva, D., Muxel, S.M., Fujita, A., Moraes, C., Nakaya, H.I., Buckeridge, M.S. and Markus, R.P. 2021. Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 carriers. Melatonin Research. 4, 1 (Jan. 2021), 189-205. DOI:https://doi.org/https://doi.org/10.32794/mr11250090.