Melatonin and brown adipose tissue: novel insights to a complex interplay
Melatonin and brown adipose tissue
Keywords:
Melatonin, Brown adipose tissue, Rhythm, Energy Metabolism, Non-shivering thermogeneses, UCP-1, Seasonality
Abstract
As a chronobiotic molecule, melatonin finely tunes a variety of physiological processes including energy metabolism, reproduction and sleep-wake cycle, collaborating for the survival of the organisms. Since its pineal production occurs exclusively during the night, melatonin is responsible for signaling the circadian and circannual cycles to the organisms. This involves different ways of action that need to be considered when analyzing its effects in a given tissue/organism. Non-shivering thermogenesis (NST) is a crucial process for homeothermic animals and increasing evidences show its importance for the energy metabolic balance due to its influence in body weight control. The highly seasonal brown adipose tissue (BAT) is the site for NST and its metabolism is importantly influenced by melatonin. This review focuses on melatonin actions over BAT and the attention should be given to the relation between this signaling molecule and such a seasonally expressed tissue.
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Published
2019-12-15
How to Cite
[1]
Olesçuck, I., Camargo, L., Carvalho, P., Souza, C., Gallo, C. and Amaral, F. 2019. Melatonin and brown adipose tissue: novel insights to a complex interplay. Melatonin Research. 2, 4 (Dec. 2019), 25-41. DOI:https://doi.org/https://doi.org/10.32794/mr11250039.
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