Serotonin, melatonin and their precursors and metabolites and vitamin D3 derivatives in honey

Biogenic amines, melatonin and secosteroids in honey

  • Tae-Kang Kim Department of Dermatology, The university of Alabama at Birmingham, Birmingham, Alabama 35294, USA
  • Adrian Fabisiak Department of Chemistry, University of Warsaw, 02-093 Warsaw, Poland
  • Pawel Brzeminski Department of Chemistry, University of Warsaw, 02-093 Warsaw, Poland
  • Russel J Reiter Department of Cell Systems and Anatomy, UT Health, Long School of Medicine, San Antonio, Texas 78229, USA
  • Andrzej T Slominski Pathology and Laboratory Medicine Service, VA Medical Center, Birmingham, Alabama35294, USA http://orcid.org/0000-0001-8963-3995
DOI: https://doi.org/10.32794/mr112500137
Keywords: melatoin, serotonin, honey, bees, AMK, AFMK, biogenic amines, secosteroids

Abstract

We are commenting recent discoveries on the presence of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK and AMK in honey. Serotonin and melatonin, products of the tryptophan metabolism, are widely produced in nature, serving as hormones, neurotransmitters, biological regulators, neurotransmitters and antioxidants, in a context dependent fashion.  Dopamine and tryptamine are important neurotransmitters across different species. Honey is used as one of the most popular healthy food substances. Detection of above molecules in honey accompanied by detection of vitamin D3 and its hydroxyderivatives, is consistent with their detection in insects and plants. Their presence in honey enhances spectrum of its beneficial effects for human health and implicates that these molecules must play important role in social insects physiology, bees development and colony functions.


Author Biography

Andrzej T Slominski, Pathology and Laboratory Medicine Service, VA Medical Center, Birmingham, Alabama35294, USA

UNIVERSITY APPOINTMENTS: 

7/2015-present                                 Professor of Pathology, University of Alabama Birmingham

4/2015-present                                 Professor of Dermatology (Endowed), University of Alabama Birmingham

4/2015-present                                 Senior Scientist, Comprehensive Cancer Centerr, Cancer Chemoprevention Program, UAB

7/2015-7/2017                                  Program Director of  Dermatopathology Fellowship

7/2014- 4/2015                                 Cancer Research Committee Member, West Clinic

7/2002-7/2015                                  Professor of Pathology (tenured on 2003), Department of Pathology and Laboratory Medicine,               

                                                          University of Tennessee HSC, Memphis, TN

7/2011-4/2015                                  Professor of Internal Medicine, Department of

                                                         Internal Medicine, University of Tennessee HSC, Memphis, TN

7/2003-7/2014                                  Director of Dermatopathology Fellowship at UTHSC

7/2003-4/2015                                  Full Member of the University of Tennessee Cancer Institute

7/2006-4/2015                                  Member of CGHS Curriculum Committee

7/2000-7/2002                                  Associate Professor, Department of Pathology, UTHSC, Memphis, TN

11/1997-6/2000                                Associate Professor, Department of Pathology,

                                                          Loyola University Medical Center, Maywood, IL

7/1993-11/1997                                Assistant Professor, Dept of Pathology and Laboratory  Medicine, Albany Med College, Albany, NY

6/1989-6/1997                                  Assistant Professor, Microbiology, Immunology & Molecular Genetics, Albany Med College, Albany, NY

5/1989-6/1990                                  Associate Investigator, Toolan Institute for Cancer Research, Bennington, Vt

1/1985-4/1989                                  Postdoctoral Fellow, Department of Dermatology, Yale University School of Medicine, New Haven, CT    

5/1983-12/1984                                Assistant Professor, Department of Biology and Human Genetics, School of Medicine, Gdansk, Poland  

CLINICAL APPOINTMENTS:  

4/2015-present                   Pathologist, Birmingham VA Medical Center

4/2015-present                   Dermatopathologist, Department of Dermatology, University of Alabama Birmingham

4/2004- 2/2015                   Dermatopathologist, UPG, Department of Pathology, UTHSC

5/2014-4/2016                   Regional One Health (previously Regional Medical Center at Memphis), Memphis, TN

5/2004-4/2014                   Regional Medical Center at Memphis, Memphis, TN

7/2003-7/2014                   Director of Dermatopathology Fellowship at UTHSC

7/2001-4/2004                   Member of Credentialing Committee, University of Tennessee Medical  Group

7/2000-4/2004                   Dermatopathologist, UTMG, Department of Pathology, UTHSC

7/1/1998-6/30/2000           Loyola University Medical Center, Maywood, IL, Director of Dermatopathology

7/1998-6/2000                   Cardinal Bernardin Cancer Center, Maywood, IL, Member of Melanoma Multidisciplinary Clinic

7/1998-6/2000                   Sun-Belt Melanoma Program (Loyola Medical Center), member

11/1997-6/30/2000            Loyola University Medical Center, Maywood, IL, Department of Pathology, Dermatopathologist/

BOARD CERTIFICATION (valid indefinitely) 

Dermatopathology: American Board of Pathology and American Board of Dermatology, 11/15/97

Anatomic Pathology: American Board of Pathology, 6/11/97


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Published
2022-09-30
How to Cite
[1]
Kim, T.-K., Fabisiak, A., Brzeminski, P., Reiter, R. and Slominski, A. 2022. Serotonin, melatonin and their precursors and metabolites and vitamin D3 derivatives in honey. Melatonin Research. 5, 3 (Sep. 2022), 374-380. DOI:https://doi.org/https://doi.org/10.32794/mr112500137.
Issue
Vol 5 No 3 (2022): Melatonin Research
Section
Commentary
DOI
https://doi.org/10.32794/mr112500137
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