Melatonin, cardiovascular disease and COVID-19: A potential therapeutic strategy?

Melatonin and cardiovascular disease in COVID-19

  • Alberto Dominguez-Rodriguez Hospital Universitario de Canarias, Department of Cardiology, Tenerife, Spain; Facultad de Ciencias de la Salud, Universidad Europea de Canarias, Tenerife, Spain and CIBER de enfermedades CardioVasculares (CIBERCV), Madrid, Spain. http://orcid.org/0000-0002-6384-6893
  • Pedro Abreu-Gonzalez Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain
  • Paul E Marik Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
  • Russel J Reiter Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, Texas, USA
DOI: https://doi.org/10.32794/mr11250065
Keywords: melatonin, cardiovascular disease, angiotensin-converting enzyme 2, COVID-19

Abstract

The mechanism for SARS-CoV-2 infection is the requisite binding of the virus to the membrane-bound form of angiotensin-converting enzyme 2 (ACE2) and internalization of the complex by the host cell. SARS-CoV-2 induced endothelial dysfunction and cardiovascular injury are probably initiated by increases in the phosphorylation levels of JAK2 and STAT3 and resultant reactive oxygen species (ROS) formation. These pathological alterations are speculated to be strikingly reversed by melatonin

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Published
2020-06-15
How to Cite
[1]
Dominguez-Rodriguez, A., Abreu-Gonzalez, P., Marik, P.E. and Reiter, R.J. 2020. Melatonin, cardiovascular disease and COVID-19: A potential therapeutic strategy?. Melatonin Research. 3, 3 (Jun. 2020), 318-321. DOI:https://doi.org/https://doi.org/10.32794/mr11250065.
Issue
Vol 3 No 3 (2020): Melatonin and COVID-19 Special Issue
Section
Letter to Editor
DOI
https://doi.org/10.32794/mr11250065
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